![]() PDD PD with dementia, PDnD PD without dementiaĪll PD patients were diagnosed according to the UK brain Bank criteria ( Gelb et al. The aims of this analyses were to compare the clinical utility of MoCA and MMSE in both PD and DLB and their sensitivity in detecting cognitive decline over time.įlow diagram: inclusion criteria for selecting participants. 2014) reported a formula for conversion from MMSE to MOCA scores in PD but not in LBD. 2012a) and the other reporting the opposite ( Hu et al. Two longitudinal studies have compared the MoCA and MMSE in PD, with one showing the MMSE to be superior ( Lessig et al. ![]() 2014), but this may reflect that the MMSE is not sensitive in capturing some DLB-specific cognitive deficits. ![]() Although findings vary, MMSE rate of decline is similar in DLB and PDD compared with AD ( Aarsland et al. The MoCA’s better sensitivity may be due to lack of ceiling effect, since it is more challenging and contains more attention-executive items than the MMSE.įew longitudinal studies have explored the rate of cognitive decline in DLB and PDD, and most of them have used only the MMSE. Cross-sectional studies suggest that the MoCA is more sensitive than the MMSE in elderly people, AD, PD, Huntington disease and DLB ( Gill et al. However, there is lack of consensus about which is best suited to assess cognition in patients with Lewy body disease (LBD i.e., PD and DLB). 1975) and the Montreal Cognitive Assessment (MoCA) ( Nasreddine et al. Two of the most commonly used cognitive screening scales are the Mini-Mental State Examination (MMSE) ( Folstein et al. 2014).Ĭognitive screening tests should be short and easy to administer, but still sufficiently sensitive to detect both mild and severe impairment, as well as different cognitive domains. Similarly, the prognosis is worse in DLB compared to AD, with shorter time to nursing home admission and death ( Oesterhus et al. For example, in PD cognitive decline is associated with reduced function, quality of life, caregiver burden and shorter time to nursing home admission ( Temlett and Thompson 2006). Accurate diagnosis and assessment of cognitive abilities is very important for patient management. The cognitive profile can vary between AD and DLB patients, with memory problems not necessarily the most prominent feature in DLB ( McKeith et al. A clinical diagnosis of DLB can be difficult because of the variability and the overlap with AD and Parkinson’s disease with dementia (PDD). 65 % of cases, respectively) ( Aarsland et al. However, in PDnD, the MoCA is a better measure of cognitive status as it lacks both ceiling and floor effects.ĭementia with Lewy bodies (DLB) is the second most common type of neurodegenerative dementia after Alzheimer’s disease (AD) (10–15 vs. MMSE and MoCA are equal in measuring the rate of cognitive changes over time in LBD. In contrast, the 1-year estimation of change did not differ between the two tests in any of the groups (Cohen’s effect <0.20 in each group). This difference was significant only in PDnD (11 vs. ![]() RSD% for the MoCA (21 %) was greater than for the MMSE (13 %) ( p = 0.03) in the whole group. Percentage of relative standard deviation (RSD%) at baseline was the measure of inter-individual variance, and estimation of change (Cohen’s d) over time was calculated. Retrospective cohort study of 265 LBD patients from an international consortium who completed both the MMSE and MoCA at baseline and 1-year follow-up ( N = 153). The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are the most commonly used scales to test cognitive impairment in Lewy body disease (LBD), but there is no consensus on which is best suited to assess cognition in clinical practice and most sensitive to cognitive decline.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |